Eosinophil Peroxidase

Eosinophil Peroxidase (EPO or EPX) is a very basic protein stored in and secreted from human eosinophil granulocytes. The main activity of EPO is that of a peroxidase, but other non-peroxidase activities have been identified. EPO is unique to eosinophils and not found in any other human cell. EPO may be measured in various biological fluids as a reflection of the turnover and activity of the eosinophil population in the body.

We provide you with the following tools to study the involvement of EPO in human disease processes

  • The mouse monoclonal antibody against EPO mab 616 of the IgG1-type is suitable for the identification of EPO in tissues by immunocytochemistry (available). We can also provide you with several other monoclonal antibodies against EPO with different epitope specificities and which may be used for the development of immunoassays of EPO.
  • We also have available a specific rabbit polyclonal antibody
  • Native EPO was purified from the granules of subjects with the hypereosinophilic syndrome(available)
  • An ELISA assay for the measurement EPO in various body fluids (available)