Eosinophil Derived Neurotoxin

Eosinophil Derived Neurotoxin (EDN), also called Eosinophil protein-X (EPX) in the past. To avoid confusion the latter name should no longer be used, since the gene of another eosinophil derived protein, Eosinophil Peroxidase (EPO), recently was renamed EPX.

EDN is a protein produced by and secreted from the human eosinophil granulocyte. EDN is a potent RNase and may be active in the anti-viral defence. Recently EDN was shown to enhance antigen processing by  cells such as the dendritic cells and therefore included in the Alarmin family of proteins.

EDN may be measured in urine, stools or blood as a reflection of the turnover and/or activity of the eosinophil population in the body.

Small amounts of EDN are found in neutrophil granulocytes.

  • The mouse monoclonal antibody against EDN mab 616 of the IgG1-type is suitable for the identification of EDN in tissues by immunocytochemistry (available). We can also provide you with several other monoclonal antibodies against EPX/EDN with different epitope specificities and which may be used for the devlopment of immunoassays of EDN.
  • We also have available a specific rabbit polyclonal antibody
  • Native EDN was purified from the granules of healthy subjects (available)
  • An ELISA assay for the measurement EDN in various body fluids (available)